S1 RNA Binding Domain Containing Protein 1 (SRBD1)

SRBD1 Contains 1 S1 motif domain. The S1 domain was originally identified in ribosomal protein S1 but is found in a large number of RNA-associated proteins. The structure of the S1 RNA-binding domain from the Escherichia coli polynucleotide phosphorylase has been determined using NMR methods and consists of a five-stranded antiparallel beta barrel. Conserved residues on one face of the barrel and adjacent loops form the putative RNA-binding site. The structure of the S1 domain is very similar to that of cold shock proteins. This suggests that they may both be derived from an ancient nucleic acid-binding protein.More information about these proteins can be found at Protein of the Month: RNA Exosomes.This entry does not include translation initiation factor IF-1 S1 domains.