SAM And SH3 Domain Containing Protein 3 (SASH3)

SLY contains an Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling . The deduced mouse and human proteins contain 381 amino acids and share 94% sequence identity. SLY has a central SH3 domain and a SAM motif in its C-terminal half. It does not have a signal peptide or transmembrane region. Northern blot analysis detected expression in lung, spleen, Peyer patches, lymph node, thymus, and bone marrow. Expression was also detected in all murine T- and B-lymphoma cell lines examined. In situ hybridization of mouse sections revealed expression limited to the T- and B-cell areas of lymph nodes, the medulla and cortex of thymus, and Peyer patches of gut; expression was not detected in lung.