SDA1 Domain Containing Protein 1 (SDAD1)

Seasonal allergic rhinitis (SAR) is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa. Although the pathogenesis of SAR remains unclear, there does appear to be a genetic predisposition to development of SAR.  The haplotype-based haplotype relative risk approach revealed that SNPs in SDA1 domain containing 1; chemokine, CXC motif, ligand (CXCL)-9; CXCL10; and CXCL11 were associated with SAR. These SNPs made up a haplotype block, and the most common haplotype of this block was transmitted preferentially to affected offspring.genetic variations in a haplotype block spanning the SDA1 domain containing 1(SDAD1) and CXC chemokine genes on 4q21 may contribute to development of SAR in the Japanese population.