SEC24 Family, Member A (SEC24A)

SEC24A and SEC24B share about 56% sequence identity, while SEC24C and SEC24D share about 52% identity. However, the identity shared between these 2 pairs is only about 20%.The deduced 1,078-amino acid protein has a calculated molecular mass of about 118 kD. The sequence is likely incomplete because it lacks the initiator ATG. RNase protection assays demonstrated that SEC24A, SEC24B , and SEC24C were expressed simultaneously in several cell lines, including lines originating from fibroblasts, hepatocytes, and lymphocytes. The major difference in expression was a constant 2- to 3-fold lower level of expression of SEC24B compared with SEC24A and SEC24C.