SET Domain Containing Protein 2 (SETD2)

The deduced 2,061-amino acid protein has a calculated molecular mass of about 231 kD. It has a putative N-terminal tyrosine phosphorylation site, a central SET domain, and a C-terminal WW/WWP domain that is followed by a putative nuclear localization signal. The C-terminal region of HBP231 corresponds to the HYPB sequence. Northern blot analysis detected a 7.5-kb transcript expressed at variable levels in all tissues examined. Western blot analysis of HeLa cells showed that HBP231 had an apparent molecular mass of 231 kD.The deduced protein contains 1,325 amino acids. RT-PCR detected low SETD2 expression in all adult and fetal tissues and specific adult brain regions examined.