SH2 Domain Containing Protein 3C (SH2D3C)

Adaptor proteins mediate the interaction between membrane receptors and transcription factors through 1 or more domains in the adaptor protein.By searching an EST database for sequences with signal transduction motifs, Lu et al. (1999) identified a cDNA encoding a deduced 698-amino acid protein, which they named NSP3 (novel SH2-containing protein-3). Sequence analysis revealed that NSP3 also contains a potential SH3 interaction domain. Northern blot analysis detected significant levels of a 3.2- and a 3.8-kb NSP3 transcript in a wide variety of tissues.