SH3 And Multiple Ankyrin Repeat Domains Protein 1 (SHANK1)

SHANK1 contains 6 N-terminal ankyrin repeats followed by SH3 and PDZ domains, 7 proline-rich regions, and a C-terminal sterile alpha motif (SAM), which has been implicated as a dimerization motif. Another SSTRIP isoform lacked the 6 ankyrin repeats and the SH3 domain. Sequence comparisons suggested that SSTRIP, together with cortactin-binding protein, form a family of cytoskeletal-anchoring proteins. Fractionation of rat brain membranes indicated that Sstrip is enriched in the postsynaptic density fraction. Northern blot analysis of various human tissues detected 9- and 7.5-kb SSTRIP transcripts in the amygdala, hippocampus, substantia nigra, and thalamus. 7.5-kb transcript was found in organs other than brain, such as heart, skeletal muscle, kidney, and liver.