SH3 Domain Containing, Ysc84 Like Protein 1 (SH3YL1)

The predicted amino acid sequence revealed a significant homology with YHRO 16c/Ysc 84, the yeast Src homology 3 domain-containing protein, for which transcripts are expressed at high levels during meiosis. The sequence identity was remarkable at the amino terminus as well as the carboxyl-terminal Src homology 3 domain, suggesting that the novel protein is a mouse homolog of the yeast protein, termed this protein Sh3yl1. An in situ hybridization experiment showed that the Sh3yl1 transcripts are expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle during mid and late anagen phases. Thus, these data suggest the possible involvement of Sh3yl1 in the development of hair follicles during the anagen phase.