SH3 Domain GRB2 Like Protein 2 (SH3GL2)

The predicted 352-amino acid SH3GL2 protein contains a C-terminal SH3 domain, which shares 92% and 84% amino acid sequence homology with the SH3 domains of SH3GL3 and SH3GL1, respectively. The SH3 domains of these proteins also show high homology to the C-terminal SH3 domain of GRB2. The N-terminal domains of SH3GL1, SH3GL2, and SH3GL3 are homologous to each other, but not to other known proteins, and are separated from the SH3 domain by a less conserved hinge segment. SH3GL1, SH3GL2, and SH3GL3 all contain a putative nuclear localization signal, potential tyrosine phosphorylation sites, and putative SH2-, SH3-, and PTB-binding sites. Northern blot analysis of several human tissues detected a 2.7-kb SH3GL2 transcript that was predominantly expressed in brain.