SHC-Transforming Protein 2 (SHC2)

Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins involved in growth factor and cytokine receptor signaling. The PTB domain of SHC1 specifically binds to the tyrosine-phosphorylated, 145-kD protein INPP5D. By screening placental and hepatoma cDNA libraries using an EST encoding a putative PTB domain-containing protein as probe, Kavanaugh and Williams (1994) identified a partial cDNA encoding SCK (SHC-like). They determined that the SCK protein contains both a PTB and an SH2 domain. Northern blot analysis indicated that unlike SHC1, which is ubiquitously expressed with very low expression in brain, SCK is expressed higher in liver than in other tissues and is expressed in brain.