SLIT And NTRK Like Protein 6 (SLITRK6)

Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins . Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors. The deduced Slitrk6 protein contains an N-terminal signal peptide, followed by 2 LRR domains, a transmembrane domain, and a cytoplasmic domain with 2 putative tyrosine phosphorylation sites. Each LRR domain is flanked by cysteine-rich regions. In situ hybridization showed that, unlike other Slitrks, which are broadly expressed in developing mouse brain, Slitrk6 expression was restricted to ventral thalamus and lateral geniculate nucleus. Expression was strong in suprafascicular nucleus.