SNW Domain Containing Protein 1 (SNW1)

SNW1, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. SKIP associated with SKI in both in vitro and in vivo assays. By analysis of mutant SKI proteins, they determined that SKIP interacts with a highly conserved region of SKI that is required for transforming activity. Cell fractionation and immunofluorescence studies revealed that SKIP, like SKI, is found within the nucleus.