SPRY Domain Containing Protein 7 (SPRYD7)

Mabuchi et al. (2001) assembled a high-resolution physical map spanning the critical region deleted in B-cell chronic lymphocytic leukemia on chromosome 13q14 and identified CLLD6. The deduced 196-amino acid protein has a calculated molecular mass of about 22 kD. Northern blot analysis detected transcripts of 1.1, 1.5, and 3.1 kb in all normal tissues and tumor cell lines examined, with highest levels in heart, skeletal muscle, and testis, and lowest levels in thymus, peripheral blood leukocytes, lymph node, and bone marrow. The different transcripts result from the use of alternate polyadenylation sites.Mabuchi et al. (2001) determined that the CLLD6 gene contains 5 exons and spans 24 kb.By genomic sequence analysis, Mabuchi et al. (2001) mapped the CLLD6 gene to chromosome 13q14.