Secretory Carrier Membrane Protein 2 (SCAMP2)

SCAMP2 belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. SCAMP2 encodes a deduced 329-amino acid protein with a calculated molecular mass of 36.6 kD. The protein shares structural features with SCAMP1 and SCAMP3, including a leucine zipper-like segment, a proline-rich element, an extended central core that includes 4 putative transmembrane domains, a polar segment, and an alanine-rich C terminus. SCAMP2 shares 54% and 56% overall sequence identity with SCAMP1 and SCAMP3, respectively, and 94% identity with the mouse homolog.