Serine/Arginine Rich Splicing Factor 7 (SRSF7)

The isolation and characterization of cDNA clones indicated that the 9G8 protein (SFRS7) is a member of the serine/arginine (SR) splicing factor family because it includes an N-terminal RNA binding domain and a C-terminal SR domain. Members of this family are thought to play key roles in alternative splicing. The RNA binding domain of 9G8 is closely related (79 to 71% identity) to those of the SR factors human SRp20 and Drosophila RBP1.The gene spans 7,745 bp and consists of 8 exons and 7 introns within the coding sequence, thus contrasting with the organization of some other genes of the SR splicing factor family. The 5-prime flanking region is GC-rich and contains basal promoter sequences and potential regulatory elements.