Sesquipedalian 1 (Ses1)
Английские синонимы
FAM109A; Family With Sequence Similarity 109, Member A; 27 kDa Inositol Polyphosphate Phosphatase-Interacting Protein A
Sesquipedalian 1 (Ses1) encodes a protein that localizes to the endosome and interacts with the enzyme, inositol polyphosphate 5-phosphatase OCRL-1. Alternate splicing results in multiple transcript variants.Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.Forms homodimers and heterodimers with FAM109B. Interacts with OCRL and INPP5B.Was named after """sesquipedalian""", an unnecessarily long description of a simple thing. Early endosome. Recycling endosome. Golgi apparatus › trans-Golgi network. Cytoplasmic vesicle › clathrin-coated vesicle. Note: Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
