Small Nuclear Ribonucleoprotein 70kDa (SNRNP70)

SNRP70 gene is greater than 44 kb, with 11 exons. SNRP70 gene is present in single copy, consists of 6 exons, and is 14 to 16 kb long.The series of reactions leading to the removal of intervening sequences from pre-mRNAs to yield mature mRNA occurs in a complex known as the spliceosome. The spliceosome contains several small nuclear ribonucleoprotein complexes (snRNPs). One of these, the U1 snRNP, contains at least 3 specific proteins. The protein contains 3 regions similar to known nucleic acid-binding proteins, and bound RNA in an in vitro assay. Multiple forms due to alternative splicing may exist, possibly with different functions in vivo. The human U1-70K snRNP protein is the major antigen recognized by anti-(U1)RNP sera from patients with autoimmune diseases.