Small Nuclear Ribonucleoprotein Polypeptide B2 (SNRPB2)

SNRPB2 associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A""". The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.By screening a human cell expression library with autoimmune sera from patients with SLE or other rheumatic diseases, Habets et al. (1987) isolated a cDNA encoding SNRPB2. The predicted 225-amino acid protein has an apparent molecular mass of 26.5 kD by SDS-PAGE.