Small Ubiquitin Related Modifier Protein 4 (SUMO4)

SUMO4 is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins""" subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene.SUMO4 carrying the met55 variant was associated with elevated levels of activated heat-shock factor transcription factors as compared with val55, and that the levels of NF-kappa-B were suppressed to an identical degree. The authors confirmed a single sumoylation site in the DNA-binding domain of HSF2 at lysine-82.