Solute Carrier Family 10, Member 4 (SLC10A4)

Northern analysis revealed that SLC10A4 mRNA is ubiquitously expressed in human tissues with the highest levels of mRNA expression in brain, placenta, and liver. In SLC10A4 -transfected CHO cells, immunoblotting analysis and immunofluorescence staining demonstrated a 49-kDa protein that is expressed at the plasma membrane and intracellular compartments. Functional analysis of SLC10A4 showed no significant taurocholate uptake in the presence of sodium when compared to untransfected CHO cells. This protein has no capacity to transport taurocholate relative to SLC10A1 ; however, given its ubiquitous tissue distribution, it may play a more active role in transporting other endogenous organic anions.