Solute Carrier Family 16, Member 6 (SLC16A6)

At the cellular level, immunohistochemical studies localized MCT2, MCT7, and MCT8 proteins in the cattle rumen, abomasum, jejunum, and caecum. Using sequence data obtained from searching an EST database with the protein sequences of several MCTs, Price et al. (1998) screened a human circulating-blood cDNA library and isolated a full-length cDNA encoding MCT7. The MCT7 cDNA predicts a 523-amino acid protein with 10 to 12 transmembrane domains. MCT7 shares between 27% and 34% amino acid identity with MCT1, MCT2, MCT4, MCT5, and MCT6. Northern blot analysis detected a 3.6-kb MCT7 mRNA in human tissues; compared to other family members, MCT7 has a unique tissue distribution. Yoon et al. (1999) noted that the SLC16A6 gene was originally called MCT6 but was subsequently renamed MCT7.