Solute Carrier Family 16, Member 9 (SLC16A9)

SLC16A9, Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates.Nine loci with significant associations to serum UA levels were found, namely the genes PDZK1, GCKR, LRRC16A, SLC16A9 and SLC22A11 together with the previously reported findings in ABCG2, SLC2A9 and SLC17A1-SLC17A3, as well as the intensively studied SLC22A12 gene encoding for URAT1. Therefore, five novel loci associated with serum UA levels emerged from this meta-analysis. The advantage of this GWA-based meta-analysis is its power to detect novel common variants with relatively small phenotypic effects on serum UA due to the large sample size.