Solute Carrier Family 22, Member 15 (SLC22A15)

Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).The deduced 577-amino acid protein contains 12 transmembrane domains. Northern blot analysis detected a 4.6-kb SLC22A15 transcript expressed at low levels in all adult and fetal tissues examined. Expression was highest in adult kidney, brain, skeletal muscle, heart, liver, placenta, and white blood cells, intermediate in lung and spleen, and lowest in thymus, small intestine, and colon.