Solute Carrier Family 22, Member 18, Antisense (SLC22A18AS)

ORCTL2S gene contains 4 exons spread over approximately 12 kb. It may have multiple transcription start sites or promoters. The ORCTL2 and ORCTL2S genes overlap in their 5-prime regions in divergent orientations, with the first exon of ORCTL2S sharing 31 bp with the second exon of ORCTL2.The largest open reading frame within the full-length ORCTL2S cDNA encodes a putative 253-amino acid protein. Since ORCTL2S shows no significant similarity to other DNA or protein sequences and lacks good matches to the Kozak and polyadenylation consensus sequences, The ORCTL2S gene may not be translated and may function in the regulation of the ORCTL2 gene. The authors were unable to determine if the ORCTL2S gene is imprinted.