Solute Carrier Family 22, Member 23 (SLC22A23)

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes.By searching a human database for SLC22 family members, Jacobsson et al. (2007) identified SLC22A23. The deduced 405-amino acid protein has 12 putative transmembrane domains. Quantitative real-time PCR detected high expression of rat Slc22a23 in several brain regions and spinal cord, and in liver, skeletal muscle, and kidney. Moderate expression was detected in adipose tissue, lung, epididymis, and heart, and weaker expression was detected in several other tissues.Jacobsson et al. (2007) stated that the SLC22A23 gene maps to chromosome 6p25.2; the mouse Slc22a23 gene maps to chromosome 19qA3.3.