Solute Carrier Family 25, Member 21 (SLC25A21)

SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.The deduced protein contains 299 amino acids and has a calculated molecular mass of 33.3 kD. The human and rat proteins share about 82% amino acid identity. SLC25A21 also shares significant identity with the ODC proteins of C. elegans (56%) and Drosophila (55%). It shares 32% and 33% identity with the ODC1 and ODC2 proteins of S. cerevisiae, respectively. RT-PCR detected SLC25A21 expression in all tissues examined.