Solute Carrier Family 25, Member 26 (SLC25A26)

Mitochondrial carriers, including SLC25A26, are a family of transport proteins found mostly in the inner membranes of mitochondria. They shuttle metabolites and cofactors through the mitochondrial membrane .The deduced 274-amino acid protein has a molecular mass of 29.4 kD. Real-time PCR of human tissues detected strong expression in testis, with moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine, and liver, and low expression in spleen. Transfected Chinese hamster ovary (CHO) cells showed SLC25A26 localized to the mitochondria.SLC25A26 protein has very narrow substrate specificity, catalyzing exchange of only S-adenosylmethionine (SAM), and that SLC25A26 catalyzed only countertransport of SAM.