Solute Carrier Family 26, Member 9 (SLC26A9)

SLC26A9 is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. The product of this gene is a highly selective chloride ion channel regulated by WNK kinases. Alternative splicing results in multiple transcript variants encoding differing isoforms.The deduced 791-amino acid protein contains an N-terminal transporter family domain, an anti-sigma factor domain, and a C-terminal PDZ-protein interacting motif. SLC26A9 is predicted to have a 9-transmembrane structure with an intracellular N-terminal domain and an extracellular C-terminal domain.