Solute Carrier Family 34, Member 1 (SLC34A1)

Magagnin et al. (1993) cloned from human kidney cortex a cDNA encoding a renal proximal tubular, brush-border membrane Na(+)-phosphate cotransporter referred to as NaPi3. Hartmann et al. (1996) reported the cloning and characterization of the mouse (Npt2) and human (NPT2) genes. The genes were cloned by screening mouse genomic and human chromosome 5-specific libraries, respectively.Hartmann et al. (1996) determined that the mouse and human NPT2 genes are approximately 16 kb and contain 13 exons Putative CAAT and TATA boxes were located, respectively, at positions -147 and -40 of the Npt2 gene and -143 and -51 of the NPT2 gene, relative to nucleotide 1 of the corresponding cDNAs. The translation initiation site was within exon 2 of both genes.