Solute Carrier Family 35, Member D1 (SLC35D1)

SLC35D1 translocated both UDP-glucuronic acid and UDP-N-acetylgalactosamine, but not other nucleotide sugars, from the cytosol into microsomal membrane vesicles. The kinetics of transport differed for the 2 substrates.SLC35D1 may participate in glucuronidation and/or chondroitin sulfate biosynthesis.The deduced 383-amino acid protein contains putative transmembrane domains. Northern blot analysis detected highest expression in liver, lowest expression in brain, and moderate expression in all other tissues and cell lines examined.The deduced protein contains 355 amino acids. Northern blot analysis detected a 7.0-kb transcript in all tissues examined. SLC35D1 colocalized with an ER marker protein, but not with a Golgi marker protein, when expressed in Chinese hamster ovary cells.