Solute Carrier Organic Anion Transporter Family, Member 2A1 (SLCO2A1)

Lu et al. (1996) screened a human kidney cDNA library and isolated human PGT. The deduced 643-amino acid protein shares 82% identity with the rat protein. It contains 12 putative transmembrane domains and 3 N-glycosylation sites. Northern blot analysis detected wide PGT distribution, with transcripts ranging from 2.1 to 10 kb. Transcripts of 4.4 to 5.1 kb, often appearing as a doublet, were expressed in most adult tissues and all fetal tissues examined. Lu et al. (1996) noted that the tissue distribution of PGT transcripts was substantially broader, and the variety of PGT transcripts was greater, in human compared with rat. First, PGT might mediate the efflux of newly synthesized PGs from cells. Second, PGT might mediate epithelial PG transport. A third possible role of PGT is that of mediating PG clearance and degradation.