Solute Carrier Organic Anion Transporter Family, Member 6A1 (SLCO6A1)

By searching databases for genes predicted to encode organic anion transporters, followed by 3-prime and 5-prime RACE and screening of a testis cDNA library, Suzuki et al. (2003) cloned human SLCO6A1, which they called GST. The deduced 719-amino acid protein has a calculated molecular mass of 79.2 kD. It contains 12 transmembrane segments, 5 predicted extracellular N-glycosylation sites, and 6 putative phosphorylation sites. RT-PCR detected GST in testis, but not in brain, heart, lung, liver, kidney, and colon.Hartz (2010) mapped the SLCO6A1 gene to chromosome 5q21.1 based on an alignment of the SLCO6A1 sequence with the genomic sequence (GRCh37).