Sorting Nexin 7 (SNX7)

SNX7 encodes a member of the sorting nexin family. Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX domain-containing proteins that interact with a variety of receptor types. ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX7 is unique in that it does not have a coiled-coil region like some of the SNX family members. Mutations in the SNX7 gene have not been shown to cause any diseases.