Sperm Protein Associated With The Nucleus, X-Linked Family, Member E (SPANXE)
Английские синонимы
Nuclear-associated protein SPAN-Xe
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa.SPANXE is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene encodes a sperm protein that contains a consensus nuclear localization signal but, although a role in spermatogenesis is suggested, the specific function of this family member has not yet been determined. SPANXD/E were expressed in 8 of 9 testicular mRNA samples examined, whereas SPANXB1 was expressed in all 9 samples.
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Московский государственный университет им. Ломоносова
Московский государственный университет им. Ломоносова
