Sterile Alpha Motif Domain Containing Protein 2 (SaMD2)

3-prime untranslated region of the SARM mRNA is almost 5 kb.The 6.5-kb transcript was the most abundant and showed highest expression in liver and kidney and weaker expression in placenta. A 0.45-kb transcript, representing an antisense RNA from the 5-prime region of the SARM gene, was also present in kidney and liver. No open reading frame was observed within this RNA sequence. In brain, only the 0.45-kb antisense RNA was detected at high abundance in the cerebellum and occipital pole and at lower levels in other brain regions. The antisense RNA was also detected at high levels in all cancer cell lines tested, irrespective of the tissue origin or metastatic potential. The protein-encoding SARM transcript was not expressed except in 1 prostate carcinoma cell line.