Stonin 1 (STON1)

STN1 includes the N-terminal 711 amino acids of the 1,182-amino acid SALF protein and has a calculated molecular mass of about 83 kD. STN1 contains an N-terminal proline-rich domain, followed by a stonin homology domain and a C-terminal domain homologous to the signal-binding domain of mu subunits of AP complexes.The deduced 1,182-amino acid protein has a molecular mass of 132 kD and contains an N-terminal region (between residues 44 and 150) rich in proline, serine, and threonine that is related to a family of proteins involved in membrane trafficking. Northern blot analysis with a probe for the 5-prime end of SALF revealed expression of a 6.5-kb transcript, with highest expression in heart, placenta, kidney, prostate, and uterus and lower expression in other tissues.