Surfeit 2 (SURF2)

SURF2 is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene shares a bidirectional promoter with SURF1, which is located on the opposite strand. The function of the encoded protein from this housekeeping gene has not yet been determined.The intergenic region is expected to have bidirectional promoter activity, as is found in mouse. This region lacks a TATA box, but is GC-rich. DNase footprint analysis showed 4 regions that interacted with HeLa cell nuclear factor complexes.the 5-prime end of each of the surfeit genes, including SURF2, is contained within a CpG island. Although the mouse Surf2 and Surf4 genes overlap at their 3-prime ends, human SURF2 and SURF4 are separated by 302 bp due to a much shorter 3-prime UTR in the human SURF2 gene.