Synergin Gamma (SYNRg)

AP1 subunit gamma-binding protein 1 is a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. Northern blot analysis of multiple rat tissues revealed ubiquitous expression of Ap1gbp1 transcripts of 4.4 to 5.6 kb. Western blot analysis of rat tissues detected 110- and 150-kD bands in brain and a single 190-kD band in liver. Immunofluorescence localization in Madin Darby bovine kidney cells showed colocalization of AP1GBP1 with gamma-adaptin within the TGN and in the cytosol.