T Complex Protein 10 (TCP10)

TCP10 is about 20 cM from TCP1 and plasminogen (PLG), which are closely linked to each other at 6q26-q27. In the mouse, the TCP10 genes and another testis-expressed locus, D17Si11, map to the proximal region of chromosome 17. The human homolog of D17Si11, designated D6S46, maps to 6p21.1-p11. In both mouse and man, the gene exists in single genomic copy. TCP10 genes map to 6q21-qter along with the human homologs of other genes from the mouse chromosome 17 region between the centromere and Pim-1. No recombination between TCP1 and PLG and found that the 2 are separated from TCP10 by about 15 cM; the corresponding mouse genes are no more than 4 cM apart. Genetic mapping with markers well localized cytogenetically placed TCP1 and PLG proximal to TCP10 and localized TCP10 to 6q27.