T Complex Protein 11 (TCP11)

The mouse tcp11 gene is located in the distal inversion of the t-complex and is developmentally regulated in the same manner as the zinc finger gene ZNF76. The 2 genes are expressed in the testis at the same time.Ragoussis et al. (1992) isolated the human homolog of tcp11. By use of a combination of somatic cell hybrids, radiation hybrids, metaphase and interphase fluorescence in situ hybridization, and pulsed field gel electrophoresis, they mapped the ZNF76 and TCP11 genes to the 6p21.3-p21.2 region and linked them to each other within 300 kb of DNA, approximately 2 Mb centromeric to the major histocompatibility complex. (The D number assigned to the human homolog of tcp11 was D6S230E.)