TATA Box Binding Protein Associated Factor 7 (TAF7)

TAF7 is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators.The protein is required for transcription by promoters targeted by RNA polymerase II.The predicted protein is 349 amino acids (40 kD) and contains 40% charged residues, which may account for its larger than expected electrophoretic mobility. The mRNA was expressed in all tissues examined. The authors showed that TAFII55 interacts with TAFII230, the largest subunit of TFIID, and with multiple transcription activators, including Sp1, YY1, USF, CTF, and adenoviral E1A.