TBC1 Domain Family, Member 15 (TBC1D15)

Tbc1d15 increased Rab7 GTPase activity and showed a lower rate of increase in activity for Rab11, but was largely inactive against Rab4 and Rab6 (RAB6A).The deduced 691-amino acid human protein shares 88% amino acid identity with its mouse homolog, and both proteins contain the TBC domain . TBC1D15 shares 46% identity with TBC1D17. Northern blot analysis of mouse tissues detected 2 variants in most tissues examined, with highest expression in heart, liver, and testis and lower expression in brain, spleen, lung, kidney, and skeletal muscle. Immunofluorescence studies showed a diffuse intracellular distribution of Tbc1d15 in transfected COS-1 cells, suggesting primarily cytosolic localization.