TBC1 Domain Family, Member 3 (TBC1D3)

TBC1D3 is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.The deduced protein contains a TBC domain found in proteins involved in RAB GTPase signaling. RT-PCR analysis of 15 human tissues detected expression of TBC1D3 in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine, and peripheral blood leukocytes.The TBC1D3 paralogs appeared to be differentially expressed in human tissues. TBC1D3 was the only paralog expressed in heart.