TBC1 Domain Family, Member 3F (TBC1D3F)

By genomic sequence analysis, Hodzic et al. (2006) identified 8 paralogs of the TBC1D3 gene on chromosome 17, including TBC1D3F, which they called paralog E. All TBC1D3 paralogs encode a deduced 549-amino acid protein, but missense changes at 6 residues among the paralogs result in 5 different TBC1D3 isoforms. The TBC1D3F and TBC1D3E genes encode identical proteins. The TBC1D3 paralogs appeared to be differentially expressed in human tissues.By genomic sequence analysis, Hodzic et al. (2006) identified 8 TBC1D3 paralogs, including the TBC1D3E gene, on chromosome 17q12. The paralogs are clustered in 2 groups of 4 genes, and each cluster spans approximately 400 kb.The authors concluded that the sudden emergence of chimeric proteins, such as that encoded by TRE2, may have contributed to hominoid speciation.