TBC1 Domain Family, Member 3G (TBC1D3G)

By genomic sequence analysis, Hodzic et al. (2006) identified 8 paralogs of the TBC1D3 gene on chromosome 17, including TBC1D3G, which they called paralog D.All TBC1D3 paralogs encode a deduced 549-amino acid protein, but missense changes at 6 residues among the paralogs result in 5 different TBC1D3 isoforms. The TBC1D3G and TBC1D3H genes encode identical proteins. The TBC1D3 paralogs appeared to be differentially expressed in human tissues.By genomic sequence analysis, Hodzic et al. (2006) identified 8 TBC1D3 paralogs, including the TBC1D3G gene, on chromosome 17q12. The paralogs are clustered in 2 groups of 4 genes, and each cluster spans approximately 400 kb.