TGFB Induced Factor Homeobox 2 Like Protein, Y-Linked (TGIF2LY)

TGIF2LY encodes a member of the TALE/TGIF homeobox family of transcription factors. This gene lies within the male specific region of chromosome Y, in a block of sequence that is thought to be the result of a large X-to-Y transposition. The C-terminus of this protein is divergent from that of its chromosome X homolog (TGIF2LX), suggesting that this protein may act as a regulator of TGIF2LX. both X- and Y-linked TGIF-like genes are specifically expressed in adult testis. By cloning and sequencing of TGIFLX homologs in hominoids and Old World monkeys, they found evidence for an open reading frame in the 8 species studied. A single basepair deletion in the human TGIFLY created a different reading frame, where the C-terminal residues shared by TGIFLX and other TGIF proteins were missing. On the whole, the findings suggested that TGIFLX/Y has a transcriptional role in testis.