THO Complex Subunit 5 (THOC5)

Mouse and human THOC5 share 95.6% amino acid identity. Both contain a central WW domain-binding motif, followed by an acidic region with 3 potential phosphorylation sites, and a leucine zipper with 4 heptad repeats. They also have 2 clusters of basic residues that may act as nuclear localization signals. Northern blot analysis detected Thoc5 in all mouse tissues examined, with highest expression in testis, liver, and heart. Among human fetal tissues, THOC5 was highly expressed in kidney and liver, with lower expression in lung and brain.The deduced 683-amino acid protein has a calculated molecular mass of 78.5 kD. Northern blot analysis detected variable expression of a 2.7-kb transcript in all tissues examined, with highest expression in skeletal muscle, followed by heart and pancreas.