TIA1 Cytotoxic Granule Associated RNA Binding Protein Like Protein 1 (TIAL1)

TIAL1 is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing.Both TIAR and TIA1 are members of a family of RNA-binding proteins containing 3 RNA-binding domains and a C-terminal auxiliary domain. Like TIA1, TIAR possesses a lysosome-targeting motif in its C-terminal auxiliary domain, suggesting that TIAR is also a cytotoxic granule-associated protein.