Tandem C2 Domains Nuclear Protein (TC2N)

Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. Syts are membrane proteins that possess tandem C2 domains (C2AB) implicated in calciumdependent phospholipid binding.Sequence analysis indicates three different C2AB classes, the members of which share a high degree of sequence similarity. All the other C2ABs are highly divergent in sequence. Nearly half of the Syt family does not exhibit calcium/phospholipid binding in comparison to Syt I, the major brain isoform.Structurally, a C2 domain consists of eight beta-strands arranged in a barrel-like structure with a total amino acid length of about 125-130. C2 domains were initially identified in the protein kinase C (PKC) family and are found in more than one hundred intracellular proteins including membrane trafficking proteins.