Tectonic 3 (TCTN3)

Tectonic3 (TCTN3) on chromosome 10 is a promising NTD candidate gene in humans. The Tectonic gene in mice,which is 58% the same to TCTN3 in humans, is crucial for proper neural development. It has yet to be determined what the specific function of TCTN3 is in humans. The success of this large-scale effort was assessed by a bioinformatics analysis of the proteins through predictions of protein domains, subcellular localizations, and possible functional roles. The SPDI collection should facilitate efforts to better understand intercellular communication, may lead to new understandings of human diseases, and provides potential opportunities for the development of therapeutics.